Peroxisome proliferator-activated receptor gamma ligand pioglitazone alters neointimal composition in a balloon-denuded and radiated hypercholesterolemic rabbit.

摘要: Peroxisome proliferator-activated receptor (PPAR)-gamma activation suppresses inflammatory response, monocyte recruitment, and vascular cell proliferation. Because inflammation, deregulated growth, migration of monocytes smooth muscle cells (VSMC) play important roles in the development neointima, we tested effect pioglitazone, a high-affinity ligand, for PPAR-gamma on neointima formation iliac arteries balloon-denuded radiated hypercholesterolemic rabbit. Rabbits were fed 1.0% cholesterol diet 7 days followed by denudation endothelial layer continued 0.15% diet. On day 32, animals divided into 2 groups. One group received (n = 7) other supplemented with 400 mg pioglitazone per kilogram. 35, area was radiated. Four weeks after radiation, sacrificed arterial segments processed morphometry immunohistochemistry. Data analysis showed that had smaller (0.85 +/- 0.36 vs. 1.41 0.56, P < 0.05), more positive VSMC (23.07 6.16 18.33 5.19, 0.04), less (16.01 5.33 21.29 4.33, fewer expressing metalloproteinase (MMP)-1 MMP-9 (3.69 0.47 4.82 0.93, 0.05 3.24 0.71 4.29 0.74, 0.05, respectively). Pioglitazone reduced neointimal modified its composition rabbit model.