Somatostatin in the brain of the cave salamander, Hydromantes genei (Amphibia, Plethodontidae): immunohistochemical localization and biochemical characterization.
作者： Maura Mathieu , Federica Bruzzone , Nicolas Chartrel , Giuliana P. Serra , Saturnino Spiga
DOI: 10.1002/CNE.20175
关键词:
摘要: The distribution of somatostatin-like immunoreactivity in the brain cave salamander Hydromantes genei (Amphibia, Plethodontidae) was investigated by using two distinct antisera raised against somatostatin-14. Most somatostatin-positive cells were detected ependymal cell layer surrounding ventricles. These possessed typical morphological characteristics tanycytes or radial glial cells. Double-labeling with an antiserum somatostatin and a monoclonal antibody fibrillary acidic protein showed that somatostatin-immunoreactive lining ventricles also exhibited GFAP-like immunoreactivity. Injection neurotracer biocytin into lateral ventricle revealed neurons did not contain In telencephalon, confined to diencephalon, addition ependyma, positive bodies found periventricular preoptic nucleus, infundibular epiphysis, subcommissural organ. metencephalon, auricula cerebelli, whereas rhombencephalon numerous seen ventricular cavity. Immunoreactive nerve fibers observed hypothalamus-median eminence complex. pituitary, discrete group pars distalis. High-performance liquid chromatography analysis extracts immunoreactive material coeluted present results show peptidergic system has more simple organization than those described frog other vertebrates. This feature is probably related expression high pedomorphic characters plethodontids. suggests that, salamander, may act as neurotransmitter and/or neuromodulator, central regulator fluid homeostasis, hypophysiotropic neurohormone.
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