Isolation of [Pro2,Met13]somatostatin-14 and somatostatin-14 from the frog brain reveals the existence of a somatostatin gene family in a tetrapod.
作者： Hubert Vaudry , Nicolas Chartrel , J.Michael Conlon
DOI: 10.1016/0006-291X(92)92409-Q
关键词:
摘要: Two somatostatin-related peptides were isolated in pure form from an extract of the brain European green frog, Rana ridibunda. The primary structure most abundant component was identical to that mammalian somatostatin-14. second component, present approximately 5% abundance somatostatin-14, established as Ala-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Met-Cys. This sequence shows two substitutions (Pro for Gly2 and Met Ser13) compared with data provide evidence a somatostatin gene family tetrapods well teleost fish.
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