Paroxysmal dyskinesias in patients with HIV infection

摘要: Objective: To determine the clinical features of paroxysmal dyskinesias among HIV type 1 (HIV-1)-seropositive patients. Background: Movement disorders have been associated with infection, although full spectrum these remains uncertain. Methods: Six adult HIV-1-seropositive patients presenting were identified. Each patient underwent metabolic, CSF, EEG, and neuroimaging studies. Results: Mean age at onset was 34.5 years five six AIDS defined. Dyskinesias focal, multifocal, or hemidystonic in four generalized another two Two had kinesigenic remaining nonkinesigenic dyskinesias. Choreoathetosis (n = 3), myoclonus 2), postural tremor 5), dysarthria 3) observed. Benzodiazepines appeared beneficial three HIV-associated dementia dyskinesia a progressive course to death. Autopsy revealed intense astrogliosis loss calbindin-positive neurons subcortical gray matter. Conclusions: Paroxysmal may present as primary HIV-1-induced neurologic syndrome. The occurrence is neuronal injury matter but mechanism unknown.