Complications of systemic oral contraceptive therapy: Neoplasm--breast, uterus, cervix and vagina.

摘要: The potential carcinogenic effect of oral contraceptive (OC) agents in the induction cancer sex hormone target organs and possibility that OCs may be important reducing risk factors for these malignant lesions are reviewed. Despite many clinical investigations no direct link between breast carcinoma or fibroadenoma has been found. 1 study purported situ uterine cervix was increased among OC users however pretherapy cytologic examinations were not done. There is evidence synthetic progestogens depress mitosis cells. association taking diethylstilbestrol during pregnancy subsequent development adenocarcinoma vagina daughters found to highly signigicant (p less than .00001). It concluded certain play a role genesis vaginal disease.