The Notch Regulator Numb Links the Notch and TCR Signaling Pathways

摘要: Both the Notch and TCR signaling pathways play an important role in T cell development, but links between these are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of also contains phosphotyrosine binding domain, suggesting that could provide link pathways. We explored this possibility by investigating physical interactions among Notch, Numb, apparatus examining consequences mutation on development. found cocluster with at APC contact during Ag-driven cell-APC both immature mature cells. Furthermore, coimmunoprecipitates components apparatus. Despite association, development activation occur normally absence perhaps due to expression related protein, Numblike. Together our data suggest signals may be integrated membrane, process.