CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden.
作者： Oliver Goodyear , Karen Piper , Naeem Khan , Jane Starczynski , Prem Mahendra
DOI: 10.1182/BLOOD-2005-02-0563
关键词:
摘要: The expression of cancer germline antigens (CGAgs) is normally restricted to the testis but also present in many types malignant cells including plasma from patients with myeloma. Because T-cell immune responses CGAg have been identified solid tumors, this may offer a novel target for immunotherapy We used 12 peptide epitopes range CGAgs screen CGAg-specific T blood multiple myeloma at various stages their disease. 15 37 responded one or more peptides and magnitude CD8+ response ranged between 0.0004% 0.1% total pool. Serial analyses showed that these were detectable individual time points during course In undergoing treatment disease relapse, was positively correlated level paraprotein. Functional specific are therefore proportion possibility approach
ashpublications.org
sci-hub.se 参考文章(43)
Volker L. Reichardt, Craig Y. Okada, Arcangelo Liso, Claudia J. Benike, Keith E. Stockerl-Goldstein, Edgar G. Engleman, Karl G. Blume, Ronald Levy, Idiotype Vaccination Using Dendritic Cells After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma—A Feasibility Study Blood. ,vol. 93, pp. 2411- 2419 ,(1999) , 10.1182/BLOOD.V93.7.2411
M Witzens, C Choi, M Bucur, M Feuerer, N Sommerfeldt, A Trojan, A Ho, V Schirrmacher, H Goldschmidt, P Beckhove, Enrichment of functional CD8 memory T cells specific for MUC1 in Bone Marrow of Multiple Myeloma Patients Cancer Cell International. ,vol. 4, pp. 1- 1 ,(2004) , 10.1186/1475-2867-4-S1-S30
Catherine Pellat-Deceunynck, Tumour-associated antigens in multiple myeloma British Journal of Haematology. ,vol. 120, pp. 3- 9 ,(2003) , 10.1046/J.1365-2141.2003.03760.X
Nicolas van Baren, F. Brasseur, D. Godelaine, G. Hames, Augustin Ferrant, Frédéric Lehmann, Marc André, C. Ravoet, C. Doyen, Giulio C Spagnoli, Marleen Bakkus, Kris Thielemans, Thierry Boon, None, Genes encoding tumor-specific antigens are expressed in human myeloma cells Blood. ,vol. 94, pp. 1156- 1164 ,(1999) , 10.1182/BLOOD.V94.4.1156
John D. M. Campbell, Gordon Cook, Susan E. Robertson, Alasdair Fraser, Kelly S. Boyd, J. Alastair Gracie, Ian M. Franklin, Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15. Journal of Immunology. ,vol. 167, pp. 553- 561 ,(2001) , 10.4049/JIMMUNOL.167.1.553
Pierre Van Der Bruggen, Yi Zhang, Pascal Chaux, Vincent Stroobant, Christophe Panichelli, Erwin S Schultz, Jacques Chapiro, Benoît J Van den Eynde, Francis Brasseur, Thierry Boon, None, Tumor-specific shared antigenic peptides recognized by human T cells Immunological Reviews. ,vol. 188, pp. 51- 64 ,(2002) , 10.1034/J.1600-065X.2002.18806.X
John D.M Campbell, Detection and enrichment of antigen-specific CD4+ and CD8+ T cells based on cytokine secretion. Methods. ,vol. 31, pp. 150- 159 ,(2003) , 10.1016/S1046-2023(03)00125-7
Guangyong Peng, Zhong Guo, Yanchun Li, Yukiko Kiniwa, Ethan M Shevach, Rong-Fu Wang, Helen Y Wang, Dean A Lee, Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands: Implications for Immunotherapy Immunity. ,vol. 20, pp. 107- 118 ,(2004) , 10.1016/S1074-7613(03)00359-5
Klaus Juul, Anne Tybjærg-Hansen, Rolf Steffensen, Steen Kofoed, Gorm Jensen, Børge Grønne Nordestgaard, Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses Blood. ,vol. 100, pp. 3- 10 ,(2002) , 10.1182/BLOOD-2002-01-0111
Mauro Provinciali, Arianna Smorlesi, Immunoprevention and immunotherapy of cancer in ageing Cancer Immunology, Immunotherapy. ,vol. 54, pp. 93- 106 ,(2005) , 10.1007/S00262-004-0539-3