Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands: Implications for Immunotherapy
作者： Guangyong Peng , Zhong Guo , Yanchun Li , Yukiko Kiniwa , Ethan M Shevach
DOI: 10.1016/S1074-7613(03)00359-5
关键词:
摘要: Regulatory T cells play an important role in the maintenance of immunological self-tolerance by suppressing immune responses against autoimmune diseases and cancer. Little is known, however, about nature physiological target antigens for CD4(+) regulatory (Treg) cells. Here we report identification LAGE1 protein as a ligand tumor-specific Treg cell clones generated from tumor-infiltrating lymphocytes (TILs) cancer patients. Phenotypic functional analyses demonstrated that they were antigen-specific expressing CD25 GITR molecules possessing suppressive activity on proliferative response naive to anti-CD3 antibody stimulation. Ligand-specific activation cell-cell contact required TIL102 exert effector These findings suggest presence at tumor sites may have profound effect inhibition
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