β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis.

摘要: Background Loss of skeletal muscle mass and weakness are common in a variety clinical conditions with both wasting associated an impairment physical function. β-Hydroxy-β-methylbutyrate (HMB) is nutrition supplement that has been shown to favorably influence protein turnover thus potentially plays role ameliorating weakness. Objectives The aim this study was investigate the efficacy HMB alone, or supplements containing HMB, on function characterized by loss Methods A systematic review meta-analysis randomized controlled trials reporting outcomes mass, strength, performed. Two reviewers independently performed screening, data extraction, risk-of-bias assessment. Outcome were synthesized through use random-effects model presented as standardized mean differences (SMDs). Results Fifteen included, involving 2137 patients. Meta-analysis revealed some evidence support effect increasing (SMD = 0.25; 95% CI: -0.00, 0.50; z 1.93; P 0.05; I2 58%) strong improving strength 0.31; 0.12, 3.25; 0.001; 0%). Effect sizes small. No bodyweight 0.16; -0.08, 0.41; 1.34; 0.18; 67%) any other outcome found. considered have low risk bias all categories. Conclusion increased conditions, although size Given many included studies, further high-quality studies should be undertaken enable interpretation translation into practice. trial registered PROSPERO CRD42017058517.