Role of calorie restriction in alleviation of age-related morphological and biochemical changes in sciatic nerve
作者： Mona G. Amer , Nehad F. Mazen , Nader M. Mohamed
DOI: 10.1016/J.TICE.2014.09.002
关键词:
摘要: Abstract Background Aging is associated with structural, functional and biochemical alterations in the nervous system. Calorie restriction (CR) was found to retard most physiological indices of aging. Objectives This work aimed investigate effect CR on age-related changes sciatic nerves. Materials methods Thirty male albino rats aged 1 month were equally divided into three groups; Group I [control adult-ad libitum AL]: fed a regular diet sacrificed at age 6 months, group II (aged-AL group): AL 18 III (aged CR) 40% calorie restricted months. Rats anesthetized nerves processed for light, electron microscope morphometric studies. Oxidative stress investigated by estimation lipid perioxidation product malondialdehyde (MDA) tissue level antioxidant enzyme; superoxide dismutase activity (SOD). Results The (AL) appeared disorganized, thick perineurium increased collagen fibers decreased g -ratio. Abnormal myelin forms seen as outfolded loops, thin denuded myelin, splitting figures interlamellar vacuoles. Schwann cells revealed vacuolated cytoplasm. There also significant increase MDA decrease SOD comparison control adult (AL). Apparent structural histomorphological improvement noticed after rats. Conclusion caused alleviating such effects.
sci-hub.se 参考文章(57)
John D. Bancroft, Marilyn Gamble, Theory and Practice of Histological Techniques ,(1990)
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
Valentina Zamboni, Matteo Tosato, Matteo Cesari, Alessandro Ferrini, The aging process and potential interventions to extend life expectancy. Clinical Interventions in Aging. ,vol. 2, pp. 401- 412 ,(2007)
Ulf T. Brunk, Alexei Terman, The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. FEBS Journal. ,vol. 269, pp. 1996- 2002 ,(2002) , 10.1046/J.1432-1033.2002.02869.X
Christopher A. Jolly, Dietary Restriction and Immune Function Journal of Nutrition. ,vol. 134, pp. 1853- 1856 ,(2004) , 10.1093/JN/134.8.1853
James L Salzer, None, Polarized Domains of Myelinated Axons Neuron. ,vol. 40, pp. 297- 318 ,(2003) , 10.1016/S0896-6273(03)00628-7
Debapriya Dutta, Riccardo Calvani, Roberto Bernabei, Christiaan Leeuwenburgh, Emanuele Marzetti, Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging Mechanisms and Therapeutic Opportunities Circulation Research. ,vol. 110, pp. 1125- 1138 ,(2012) , 10.1161/CIRCRESAHA.111.246108
Sunitha Rangaraju, David Hankins, Irina Madorsky, Evgenia Madorsky, Wei-Hua Lee, Christy S. Carter, Christiaan Leeuwenburgh, Lucia Notterpek, Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging Aging Cell. ,vol. 8, pp. 178- 191 ,(2009) , 10.1111/J.1474-9726.2009.00460.X
Stephen Anton, Christiaan Leeuwenburgh, None, Fasting or caloric restriction for Healthy Aging Experimental Gerontology. ,vol. 48, pp. 1003- 1005 ,(2013) , 10.1016/J.EXGER.2013.04.011
Tim Hofer, Stephane Servais, Arnold Young Seo, Emanuele Marzetti, Asimina Hiona, Shashank Jagdish Upadhyay, Stephanie Eva Wohlgemuth, Christiaan Leeuwenburgh, Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mechanisms of Ageing and Development. ,vol. 130, pp. 297- 307 ,(2009) , 10.1016/J.MAD.2009.01.004