Methods of Assessing Toxic Interactions in Vitro: Experimental Design and Data Analysis

摘要: The history, theory, statistics, and development of mathematical models that assess biological responses to combinations chemicals are well represented in the literature. A relative paucity literature focuses on actual application methods experimental guidelines for assessing toxic interactions. wide variety use—some complicated, many nonideal—confounds comparison results from different laboratories. This communication is not a comprehensive exposition appropriate study or pharmacologic interactions chemical agents. modular approach presented here intended offer unifying framework such studies provide simple yet versatile procedure new investigators this area. components, as designs models, can be (re)selected suit specific research questions test generality conclusions without altering over...