Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites.

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DOI: 10.1093/OXFORDJOURNALS.MOLBEV.A040082

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摘要: Felsenstein's maximum-likelihood approach for inferring phylogeny from DNA sequences assumes that the rate of nucleotide substitution is constant over different sites. This assumption sometimes unrealistic, as has been revealed by analysis real sequence data. In present paper method extended to case where rates sites are described gamma distribution. A numerical example presented show fits data better than do previous models.

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