Critical role of FOXO3a in carcinogenesis.

摘要: FOXO3a is a member of the FOXO subfamily forkhead transcription factors that mediate variety cellular processes including apoptosis, proliferation, cell cycle progression, DNA damage and tumorigenesis. It also responds to several stresses such as UV irradiation oxidative stress. The function regulated by complex network processes, post-transcriptional suppression microRNAs (miRNAs), post-translational modifications (PTMs) protein–protein interactions. widely implicated in diseases, particularly malignancy breast, liver, colon, prostate, bladder, nasopharyngeal cancers. Emerging evidences indicate acts tumor suppressor cancer. frequently inactivated cancer lines mutation gene or cytoplasmic sequestration protein. And its inactivation associated with initiation progression In experimental studies, overexpression inhibits tumorigenic potential, invasiveness cells, while silencing results marked attenuation protection against role both normal physiology well development have presented great challenge formulating an effective therapeutic strategy for this review, we summarize recent findings overview current understanding influence progression.