Biologically-relevant interactions, phase separations and thermodynamics of chitosan–mucin binary systems

摘要: Abstract This is a study of the interactions between chitosan and mucin, main oral/gastrointestinal thickener. Phase compatibility separations were mapped pH 1 7, where region strong phase separation exists upon co-existence mucin at about 2:1 wt ratios. No are discernible lower values. ζ-potential data suggest that electrostatic expected only below 5. Fluorimetry show no direct bonds form while associations arise from random nonlocalized events, such as nonspecific dispersion (hydrophobic) leading to polymeric entanglements. At 3, two binding regimes exist, one low concentrations involving both enthalpic entropic interactions, second higher ratios, purely character, which related other interactions. A combination oscillational shear rheometry shows that, addition, an inflexible coil conformation reverts into shear-thinning, highly entangled network, can be described by fluorimetry data. The above results highlighted categorically (saliva) directly involved in promoting aggregation and/or fusion chitosan-mucin complex.