Codon reading patterns in Saccharomyces cerevisiae mitochondria based on sequences of mitochondrial tRNAs

作者: Annie-Paule Sibler , Guy Dirheimer , Robert P. Martin

DOI: 10.1016/0014-5793(86)80064-3

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摘要: Abstract The sequences of Saccharomyces cerevisiae mitochondrial tRNA 1 Arg , 2 Gly Lys Leu and Pro are reported. Special structural features were found in which has A 8 C 21 48 instead the constant residues U pyrimidine 48, a excluded from basepairing bulging out TΨC stem. belong to two-codon families ending purine, have modified uridine wobble position, prevents misreading U. It is likely be 5-carboxymethylaminomethyluridine. an unmodified position allowing reading all four codons four-codon family. However, minor species belongs CGN family, position. This very unusual feature raises problem mechanism by CGA, CGG CGC recognized.

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