Targeting neural precursors in the adult brain rescues injured dopamine neurons

摘要: In Parkinson's disease, multiple cell types in many brain regions are afflicted. As a consequence, therapeutic strategy that activates general neuroprotective response may be valuable. We have previously shown Notch ligands support neural precursor cells vitro and vivo. Here we show precursors express the angiopoietin receptor Tie2 injections of angiopoietin2 activate adult brain. Signaling downstream regulate blood vessel formation. brain, ligand Dll4 with opposing effects on density vessels. A model disease was used to rescue injured dopamine neurons motor behavioral improvement. combination growth factors little impact vasculature retains ability stimulate protect neurons. The cellular pharmacological basis achieved by these single treatments merits further analysis.