Bacterial plasmid addiction systems and their implications for antibiotic drug development.

摘要: Bacteria frequently carry mobile genetic elements capable of being passed to other bacterial cells. An example this is the transfer plasmids (small, circular DNA molecules) that often contain antibiotic resistance genes from one bacterium another. Plasmids have evolved mechanisms ensure their survival through generations by employing segregation and replication machinery plasmid addiction systems. Plasmid systems utilize a post-segregational killing cells not received plasmid. In review, types are described as well prevalence in resistant bacteria. Lastly, possibility targeting these for treatment infections explored.