Epstein-Barr virus and its association with disease - a review of relevance to general practice.

摘要: General practitioners encounter the vast majority of patients with Epstein-Barr virus-related disease, i.e. infectious mononucleosis in children and adolescents. With expanding knowledge regarding multifaceted role virus both benign malignant disease we chose to focus this review on conditions relevance general practitioners. A PubMed Google Scholar literature search was performed using PubMed’s MeSH terms virus/infectious regard complications associated conditions. In present review, these included three early complications; hepatitis, splenic rupture airway compromise, as well possible late conditions; lymphoproliferative cancers, multiple sclerosis, rheumatoid arthritis, chronic active infection. This thus highlights recent advances understanding pathogenesis, focusing management, acute complications, referral indications potentially Hepatitis is a common self-limiting complication should be monitored liver tests more symptomatic cases. Splenic rare. Most cases are seen within 3 weeks after diagnosis may occur spontaneously. There no consensus safe return physical activities, ultrasonic assessment spleen size provide best estimate risk. Airway compromise due tonsil enlargement encountered minority treated systemic corticosteroids during hospitalization. Association between especially Hodgkin lymphoma Burkitt lymphoma, well-established. infection/infectious risk factor for sclerosis has been documented linked genetic susceptibility. Chronic infection However, practitioner aware differential persisting symptoms than 3 months.