Role of wild-type p53-induced phosphatase 1 in cancer (Review)
作者： Zhi-Peng Wang , Ye Tian , Jun Lin
DOI: 10.3892/OL.2017.6685
关键词:
摘要: Wild-type p53-induced phosphatase (Wip1) is a member of the protein type 2C family and an established oncogene due to its dephosphorylation several tumor suppressors negative control DNA damage response system. It has been reported dephosphorylate p53, ataxia telangiectasia mutated, checkpoint kinase 1 p38 mitogen activated kinases, forming feedback loops inhibit apoptosis cell cycle arrest. Wip1 serves major role in tumorigenesis, progression, invasion, distant metastasis various types human cancer. Therefore, it may be potential biomarker therapeutic target diagnosis treatment Furthermore, previous evidence revealed new for regulation chemotherapy resistance. In present review, current knowledge on cancer discussed, as well novel function
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