Effectiveness of inhaled tobramycin in eradicating Pseudomonas aeruginosa in children with cystic fibrosis

摘要: Abstract Background Inhaled tobramycin therapy has been shown to be efficacious in clinical trials for the eradication of initial Pseudomonas aeruginosa infection children with cystic fibrosis (CF). However, effectiveness different regimens eradicating P. and preventing development chronic actual settings yet determined. Methods This was an observational study ( from 2005–2012 based on data collected Toronto CF Database medical charts. Patients who received inhaled (80mg/2ml twice daily 365days) were compared those inhalation solution (TIS) (300mg/5ml 28days) respect infection. We also examined risk factors recurrence Results During period, 65 patients identified incident , which 7 (11%) failed therapy. Eradication failure similar between two treatment groups. A total 4 (6%) developed 12months following end no differences Female gender, older age, pancreatic insufficiency, lower lung function worse nutritional status as Conclusions Both have practice. Further work is needed, however, identify patient characteristics bacterial that play a role failure, order develop more effective antimicrobial rescue strategies.