Endotypes of difficult-to-control asthma in inner-city African American children

摘要: African Americans have higher rates of asthma prevalence, morbidity, and mortality in comparison with other racial groups. We sought to characterize endotypes childhood severity American patients an inner-city pediatric population. Baseline blood neutrophils, eosinophils, 38 serum cytokine levels were measured a sample 235 asthmatic children (6–17 years) enrolled the NIAID (National Institute Allergy Infectious Diseases)-sponsored Asthma Phenotypes Inner City (APIC) study (ICAC (Inner Consortium)-19). Cytokines quantified using MILLIPLEX panel analyzed on Luminex analyzer. Patients classified as Easy-to-Control or Difficult-to-Control based required dose controller medications over one year prospective management. A multivariate variable selection procedure was used select cytokines associated versus asthma, adjusting for age, sex, neutrophils. In children, 12 significant predictors (n = 235). CXCL-1, IL-5, IL-8, IL-17A positively while IL-4 IL-13 asthma. Using likelihood ratio testing, it observed that addition eosinophils improved fit model. population, significantly contributed definition children. Mixed responses characterized by TH2 (IL-5) TH17-associated Collectively, these data may contribute risk stratification