Protein kinase B/Akt at a glance

作者: Elisabeth Fayard , Lionel A Tintignac , Anne Baudry , Brian A Hemmings

DOI: 10.1242/JCS.02724

关键词:

摘要: Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears be central player in regulation metabolism, cell survival, motility, transcription and cell-cycle progression. Conserved from primitive metazoans humans, PKB belongs

参考文章(48)
D. R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, B. A. Hemmings, Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. ,vol. 15, pp. 6541- 6551 ,(1996) , 10.1002/J.1460-2075.1996.TB01045.X
Michael Huber, Cheryl D Helgason, Jacqueline E Damen, Michael Scheid, Vincent Duronio, Ling Liu, Mark D Ware, R.Keith Humphries, Gerald Krystal, The role of SHIP in growth factor induced signalling. Progress in Biophysics & Molecular Biology. ,vol. 71, pp. 423- 434 ,(1999) , 10.1016/S0079-6107(98)00049-2
Kathryn L. Schwertfeger, Monica M. Richert, Steven M. Anderson, Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice Molecular Endocrinology. ,vol. 15, pp. 867- 881 ,(2001) , 10.1210/MEND.15.6.0663
Alex Toker, Alexandra C. Newton, Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site Journal of Biological Chemistry. ,vol. 275, pp. 8271- 8274 ,(2000) , 10.1074/JBC.275.12.8271
Effat S Emamian, Diana Hall, Morris J Birnbaum, Maria Karayiorgou, Joseph A Gogos, Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nature Genetics. ,vol. 36, pp. 131- 137 ,(2004) , 10.1038/NG1296
Derek P. Brazil, Jongsun Park, Brian A. Hemmings, PKB binding proteins. Getting in on the Akt. Cell. ,vol. 111, pp. 293- 303 ,(2002) , 10.1016/S0092-8674(02)01083-8
Vuk Stambolic, Akira Suzuki, José Luis de la Pompa, Greg M Brothers, Christine Mirtsos, Takehiko Sasaki, Jurgen Ruland, Josef M Penninger, David P Siderovski, Tak W Mak, Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN Cell. ,vol. 95, pp. 29- 39 ,(1998) , 10.1016/S0092-8674(00)81780-8
Norihiro Ohba, Sumiko Kiryu-Seo, Mitsuyo Maeda, Michinari Muraoka, Masamitsu Ishii, Hiroshi Kiyama, Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion Neuroscience Letters. ,vol. 359, pp. 159- 162 ,(2004) , 10.1016/J.NEULET.2004.02.029
Sujata Persad, Sarah Attwell, Virginia Gray, Nasrin Mawji, Jing Ti Deng, Dan Leung, Jun Yan, Jasbinder Sanghera, Michael P. Walsh, Shoukat Dedhar, Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. Journal of Biological Chemistry. ,vol. 276, pp. 27462- 27469 ,(2001) , 10.1074/JBC.M102940200
Yuko Kawakami, Hajime Nishimoto, Jiro Kitaura, Mari Maeda-Yamamoto, Roberta M. Kato, Dan R. Littman, David J. Rawlings, Toshiaki Kawakami, Protein Kinase C βII Regulates Akt Phosphorylation on Ser-473 in a Cell Type- and Stimulus-specific Fashion Journal of Biological Chemistry. ,vol. 279, pp. 47720- 47725 ,(2004) , 10.1074/JBC.M408797200