Human papillomavirus infection as a prognostic marker for lung adenocarcinoma: a systematic review and meta-analysis.

摘要: // Lanwei Guo 1 , Shuzheng Liu Shaokai Zhang Qiong Chen Meng Peiliang Quan and Xibin Sun Department of Cancer Epidemiology, Henan Office for Control Research, The Affiliated Hospital Zhengzhou University, Hospital, Zhengzhou, China Correspondence to: XiBin Sun, email: xbsun21@sina.com Keywords: HPV, lung cancer, prognosis, meta-analysis Received: July 26, 2016     Accepted: February 08, 2017     Published: 24, 2017 ABSTRACT Although a number studies have investigated the association between human papillomavirus (HPV) cancer results remain inconsistent. We therefore conducted epidemiologic to address this issue. Searches MEDLINE EMBASE electronic databases from their inception until June 30, 2016 yielded nine involving total 1,205 cases that were used conduct meta-analysis. Study-specific risk estimates pooled using random-effects model. hazard ratio (HR) comparing HPV-positive HPV-negative cancers 1.00 (95% confidence interval (CI): 0.78-1.28) was not significantly correlated with overall survival. However, adenocarcinoma patients HPV infections exhibited survival benefit compared those without infection (HR=0.69, 95% CI: 0.50-0.96). This suggests is prognostic marker in adenocarcinoma. To further elucidate epidemiology pathogenesis future large prospective are encouraged stratify analysis based on pathological type clinical stage cancer.