Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults
作者： M. Ehrnebo , S. Agurell , B. Jalling , L. O. Bor�us
DOI: 10.1007/BF00565004
关键词:
摘要: The binding to human plasma proteins of ampicillin, α-azidobenzylpenicillin, benzylpenicillin, phenobarbital and diphenylhydantoin was studied by equilibrium dialysis labelled compounds. Human foetal neonatal had very low capacities for all five drugs as compared with from adults. Hyperbilirubinemia in the period further decreased capacity. age dependence drug activity should be taken into account when analysing pharmacological effects foetuses newborn children.
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