Castanospermine, Swainsonine and Related Polyhydroxy Alkaloids: Structure, Distribution and Biological Activity
作者： Linda E. Fellows , Geoffrey C. Kite , Robert J. Nash , Monique S. J. Simmonds , Anthony M. Scofield
DOI: 10.1007/978-1-4613-0835-5_11
关键词:
摘要: Alkaloids which are inhibitors of glycosidases now believed to be widespread in plants and microorganisms. Those isolated date carry several hydroxyl substituents on a ring configuration that suggests structural resemblance monosaccharides. Despite their relatively recent detection (most have been discovered during the last ten years), they providing molecular biologists with tools probe many hitherto intractable problems biology, including cancer metastasis, viral infectivity immune response. One, castanospermine, is under evaluation as drug for clinical management HIV infection (AIDS). This paper outlines range, natural distribution biological activity.
springer.com
springerlink.com参考文章(88)
Samulitis Bk, Lee Sm, Goda T, Koldovský O, Inhibitory mechanism of acarbose and 1-deoxynojirimycin derivatives on carbohydrases in rat small intestine Drugs Under Experimental and Clinical Research. ,vol. 13, pp. 517- 524 ,(1987)
R.J. Nash, L.E. Fellows, A.C. Plant, G.W.J. Fleet, A.E. Derome, P.D. Baird, M.P. Hegarty, A.M. Scofield, Isolation from and x-ray crystal structure of 3,8-diepialexine, (1r,2r,3s,7s,8r)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2s,3r,4r,5s,6r)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol] Tetrahedron. ,vol. 44, pp. 5959- 5964 ,(1988) , 10.1016/S0040-4020(01)81454-X
D.Wyn C. Jones, Robert J. Nash, E.Arthur Bell, J.Michael Williams, Identification of the 2-hydroxymethyl-3,4-dihydroxypyrrolidine (or 1,4-dideoxy-1,4-iminopentitol) from and from as the (2R, 3R, 4S)-isomer by the synthesis of its enantiomer. Tetrahedron Letters. ,vol. 26, pp. 3125- 3126 ,(1985) , 10.1016/S0040-4039(00)98635-0
B. Burke, K. Matlin, E. Bause, G. Legler, N. Peyrieras, H. Ploegh, Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins. The EMBO Journal. ,vol. 3, pp. 551- 556 ,(1984) , 10.1002/J.1460-2075.1984.TB01845.X
A. Hadwiger, H. Niemann, A. Käbisch, H. Bauer, T. Tamura, Appropriate glycosylation of the fms gene product is a prerequisite for its transforming potency. The EMBO Journal. ,vol. 5, pp. 689- 694 ,(1986) , 10.1002/J.1460-2075.1986.TB04268.X
Hans-Jürgen Rehm, H Pape, Microbial products II VCH , Distribution, USA and Canada, VCH Publishers. ,(1986)
A.D. Elbein, P.R. Dorling, K. Vosbeck, M. Horisberger, Swainsonine prevents the processing of the oligosaccharide chains of influenza virus hemagglutinin. Journal of Biological Chemistry. ,vol. 257, pp. 1573- 1576 ,(1982) , 10.1016/S0021-9258(19)68070-1
Patrick S. Herendeen, Anne Bruneau, Charles H. Stirton, Peter H. Raven, R. M. Polhill, Advances in legume systematics Royal Botanic Gardens. ,(1981)
T Nida, S Inouye, T Tsuruoka, The structure of nojirimycin, a piperidinose sugar antibiotic. The Journal of Antibiotics. ,vol. 19, pp. 288- 292 ,(1966)
Auxin-indnced changes in barley coleoptile cell wall composition Plant and Cell Physiology. ,vol. 19, pp. 1217- 1223 ,(1978) , 10.1093/OXFORDJOURNALS.PCP.A075702