Approaches to the development of selective inhibitors of vascular smooth muscle cell proliferation

摘要: Abnormal proliferation of VSMC is a feature atheromatous plaques and responsible for obstructive neointimal lesions at the sites mechanical or immunological intimal damage. We have discussed approaches to development specific inhibitors based firstly on studies mechanism action known secondly identification genes which are unique necessary proliferation. The effects angiotensin converting enzyme inhibitors, heparin hexamethylene bisacetamide been discussed. Each these types agent has shown inhibit in vitro and/or vivo. Examination mechanisms by agents reveals that transforming growth factor beta an important mediator their processes de-differentiation independently regulated. Studies aimed identifying involved early stage but already provided strong evidence support hypothesis vessel wall heterogeneous contain subpopulation cells with enhanced proliferative capacity. Identification expressed may allow be developed shed light pathogenesis lesions.