Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer
作者： Hamid Maadi , Abdolvahab Moshtaghian , Masoumeh Fakhr Taha , Seyed Javad Mowla , Asiye Kazeroonian
DOI: 10.1016/J.BIOCEL.2016.11.004
关键词:
摘要: The miR-302 family is one of the main groups microRNAs, which are highly expressed in embryonic stem cells (ESCs). Previous reports have indicated that can reduce proliferation rate some cancer while compromising on their oncogenic potential at same time without having effect normal somatic cells. In this study we aimed to further investigate role cluster multiple signaling pathways using A-375 melanoma and HT-29 colorectal Our results indicate has modulate properties through inhibition proliferation, angiogenesis invasion, reversal epithelial-to-mesenchymal transition (EMT) these We showed for first overexpression sensitized hypoxia also selective BRAF inhibitor vemurafenib. MiR-302 a pleiotropically acting miRNA may significant implications controlling progression invasion. It acts reprogramming process, global multitude cellular events. propose by epigenetic factors, especially miRNAs might provide an efficient tool those with more invasive nature.
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