The protein kinase B/Akt signalling pathway in human malignancy.

作者: Karleen M Nicholson , Neil G Anderson

DOI: 10.1016/S0898-6568(01)00271-6

关键词:

摘要: … of this review is to discuss potential mechanisms by which PKB/Akt signalling could contribute to cancer progression. Several recent reviews … The role of 14-3-3 proteins in this process is …

参考文章(191)
Dominic Scudiero, Maryla Krajewska, Ahmed Shabaik, Stanislaw Krajewski, Hong Gang Wang, Juan M. Zapata, Timothy G. Myers, Gabriella Tudor, Edward A. Sausville, George S. Johnson, John C. Reed, Shinichi Kitada, Xin Zhang, Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines. American Journal of Pathology. ,vol. 152, pp. 51- 61 ,(1998)
Floyd H. Thompson, Mark A. Nelson, Jeffrey M. Trent, Xin-Yuan Guan, Yun Liu, Jin-Ming Yang, Julia Emerson, Laurence Adair, Julie Wymer, Celia Balfour, Kathy Massey, Ronald Weinstein, David S. Alberts, Raymond Taetle, Amplification of 19q13.1–q13.2 sequences in ovarian cancer: G-band, FISH, and molecular studies Cancer Genetics and Cytogenetics. ,vol. 87, pp. 55- 62 ,(1996) , 10.1016/0165-4608(95)00248-0
Noor EMBI, Dennis B. RYLATT, Philip COHEN, Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle FEBS Journal. ,vol. 107, pp. 519- 527 ,(2005) , 10.1111/J.1432-1033.1980.TB06059.X
Jacqueline A. Lees, Elad Gil, Liang Ping Weng, Charis Eng, Charis Eng, Patricia L M Dahia, Wendy M. Smith, Ulrike Ziebold, PTEN Suppresses Breast Cancer Cell Growth by Phosphatase Activity-dependent G1 Arrest followed by Cell Death Cancer Research. ,vol. 59, pp. 5808- 5814 ,(1999)
Michael F. Olson, Hugh F. Paterson, Christopher J. Marshall, Signals from Ras and Rho GTPases interact to regulate expression of p21 Waf1/Cip1 Nature. ,vol. 394, pp. 295- 299 ,(1998) , 10.1038/28425
M. Ramachandra, I. W. Cheney, M.-T. Vaillancourt, S. T. C. Neuteboom, R. Bookstein, Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes. Cancer Research. ,vol. 59, pp. 2318- 2323 ,(1999)
Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo, Russell Baldocchi, Tony Godfrey, Colin Collins, Daniel Pinkel, Bethan Powell, Gordon B. Mills, Joe W. Gray, PIK3CA is implicated as an oncogene in ovarian cancer Nature Genetics. ,vol. 21, pp. 99- 102 ,(1999) , 10.1038/5042
Stefanie Dimmeler, Ingrid Fleming, Beate Fisslthaler, Corinna Hermann, Rudi Busse, Andreas M. Zeiher, Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature. ,vol. 399, pp. 601- 605 ,(1999) , 10.1038/21224
Osman Nidai Ozes, Lindsey D Mayo, Jason A Gustin, Susan R Pfeffer, Lawrence M Pfeffer, David B Donner, None, NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase Nature. ,vol. 401, pp. 82- 85 ,(1999) , 10.1038/43466