Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus

摘要: Progestogenic stimulation of both the ventromedial nucleus hypothalamus (VMH) and ventral tegmental area (VTA) is critical for normal receptivity in estrogen-primed hamsters. However, anatomical biochemical studies have identified very few estrogen-induced progestin receptors rodent midbrain. To determine whether progesterone might be working on membrane neurons VTA, 3-CMO BSA (P-3-BSA) was applied intracranially. The size P-3-BSA makes it relatively impermeable to cell membrane. Ovariectomized hamsters were implanted with 2 chronic cannulae, one aimed at VMH other contralateral VTA. These animals then tested sexual after progesterone-containing tubes inserted just dorsal inserts above following week, again contents reversed. Animals progestogenic VTA receptive yet those not receptive. data suggest that capable facilitating within by actions non-genomic effects require concurrent genomic activation hypothalamus.