Pharmacogenomics and its potential impact on drug and formulation development.

摘要: Recent advances in genomic research have provided the basis for new insights into importance of genetic and markers during different stages drug development. A field research, pharmacogenomics, which studies relationship between effects genome, has emerged. Structural pharmacogenomics maps complete DNA sequences whole genomes (genotypes) including individual variations, functional assesses expression levels thousands genes one single experiment. Together, these two areas generated massive databases, become a challenge informatics fostered branch bioinformatics. If skillfully used, databases by together with data mining on Web promise to improve development process variety areas: identification targets, evaluation toxicity, classification diseases, formulations, assessment response treatment, post-marketing applications, personalized medicines.