Subependymal giant-cell astrocytomas in pediatric tuberous sclerosis disease : When should we operate?

摘要: OBJECTIVE: A small percentage of tuberous sclerosis patients will develop a subependymal giant-cell astrocytoma. Given the morbidity and mortality when such lesion is left undiagnosed, successive follow-up imaging in pediatric has been recommended. Surgical removal become procedure choice; however, timing this surgery still controversial subject. By analyzing our own series data, as well other published series, we have attempted to reach consensus on benefits early versus late surgery. METHODS: We retrospectively reviewed 19 treated surgically for intraventricular tumors Foch Hospital at Fondation Adolphe de Rothschild Paris, France, analyzed reports from 1980 2006. RESULTS: The results population, (15 series), indicate that subependymalgiant-cell astrocytomas good prognosis macroscopically total resection performed. In residual lesions tended enlarge, but remaining stable reported. Careful examination should be undertaken because recurrences do occur. Larger or symptomatic tend higher morbidity. CONCLUSION: think any fulfilling criteria astrocytoma previously described literature (lesion around foramen Monro, greater than 5 mm, with incomplete calcifications) removed soon clear evidence growth confirmed.