High performance liquid chromatographic determination of some guaiphenesin-containing cough-cold preparations
作者： Mohamed A. Korany , Ossama T. Fahmy , Hoda Mahgoub , Hadir M. Maher
DOI: 10.1016/J.JARE.2010.09.005
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摘要: Abstract This paper presents different HPLC methods for the simultaneous determination of some guaiphenesin-containing cough-cold preparations. Three pharmaceutically available combinations were analyzed: salbutamol sulfate (SAL) and guaiphenesin (GUA), combination I; ascorbic acid (ASC), paracetamol (PAR) II; theophylline anhydrous (THE), (GUA) ambroxol hydrochloride (AMB), III. A 250 × 4.6 mm C-18 column was used all combinations. The mobile phase three consisted a mixture methanol 0.01 M aqueous phosphate buffer solution. pH adjusted to 3.2, 6.2 3.8 I, II III, respectively. proposed successfully applied investigated drugs, both in synthetic mixtures pharmaceutical preparations, without any matrix interference with high precision accuracy. Different aspects analytical validation are presented text.
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sci-hub.se 参考文章(32)
Michael Z Kagan, Normal-phase high-performance liquid chromatographic separations using ethoxynonafluorobutane as hexane alternative. I. Analytical and chiral applications. Journal of Chromatography A. ,vol. 918, pp. 293- 302 ,(2001) , 10.1016/S0021-9673(01)00764-6
André F. Lavorante, Cherrine K. Pires, Boaventura F. Reis, Multicommuted flow system employing pinch solenoid valves and micro-pumps. Spectrophotometric determination of paracetamol in pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 42, pp. 423- 429 ,(2006) , 10.1016/J.JPBA.2006.04.013
James N. Miller, Jane C. Miller, Statistics and Chemometrics for Analytical Chemistry ,(2001)
A ARESTA, F PALMISANO, C ZAMBONIN, Simultaneous determination of caffeine, theobromine, theophylline, paraxanthine and nicotine in human milk by liquid chromatography with diode array UV detection Food Chemistry. ,vol. 93, pp. 177- 181 ,(2005) , 10.1016/J.FOODCHEM.2004.11.013
Weng Naidong, Yu-Luan Chen, Wilson Shou, Xiangyu Jiang, Importance of injection solution composition for LC-MS-MS methods. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 26, pp. 753- 767 ,(2001) , 10.1016/S0731-7085(01)00439-3
Xiaohui Xu, J. T. Stewart, MEKC DETERMINATION OF GUAIFENESIN, PSEUDOEPHEDRINE, AND DEXTROMETHORPHAN IN A CAPSULE DOSAGE FORM Journal of Liquid Chromatography & Related Technologies. ,vol. 23, pp. 1- 13 ,(2000) , 10.1081/JLC-100101431
Eamon McEvoy, Sheila Donegan, Joe Power, Kevin Altria, Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 44, pp. 137- 143 ,(2007) , 10.1016/J.JPBA.2007.02.025
Xingnan Li, Adrian A. Franke, Fast HPLC–ECD analysis of ascorbic acid, dehydroascorbic acid and uric acid Journal of Chromatography B. ,vol. 877, pp. 853- 856 ,(2009) , 10.1016/J.JCHROMB.2009.02.008
A. Rodríguez-Bernaldo de Quirós, M. Fernández-Arias, J. López-Hernández, A screening method for the determination of ascorbic acid in fruit juices and soft drinks Food Chemistry. ,vol. 116, pp. 509- 512 ,(2009) , 10.1016/J.FOODCHEM.2009.03.013
S.H.R.A. Mazhar, H. Chrystyn, New HPLC assay for urinary salbutamol concentrations in samples collected post-inhalation Journal of Pharmaceutical and Biomedical Analysis. ,vol. 50, pp. 175- 182 ,(2009) , 10.1016/J.JPBA.2009.04.006