Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Caucasian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction with Androgen Receptor CAG Repeat Polymorphisms
作者： David K. Moscatello
DOI: 10.21236/ADA410564
关键词:
摘要: Abstract : We are investigating the effect of a polymorphic epidermal growth factor receptor(EGFR) gene intron 1 CA repeat on prostate cancer(CaP) development, alone or in combination with known androgen receptor CAG polymorphism. will characterize these repeats DNA from African-American and Caucasian men CaP. The data be analyzed for any correlation using both parameters clinical outcome (age onset, rapid progression, metastasis. Human Subjects Protocol was approved by US Army MRMC HSRRB 24 November 2003. However, resignation study coordinator at Cooper Hospital/ University Medical Center last year failure my collaborator to train new timely manner resulted further delays initiating subject recruitment. Fortunately, collaborators affiliated Thomas Jefferson University(TJU) have agreed participate study. This site has been DOD also Protocol. Subject recruitment TJU initiated mid-February this year. Since began, eighty-seven (87) subjects entered study, we anticipate achieving our goal 113 more (300 total) CaP mid-2007. A urologist now available cooper Hospital. requested no-cost extension grant through June 2007 order complete research.
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