The uptake and disposition of enflurane during and following anesthesia in obese and non-obese humans

摘要: The disposition of enflurane, a volatile halogenated anesthetic 9 was studied in obese (n==24) and non-obese (n=8) informed consenting adult.human subjects undergoing elective intraabdominal surgical procedures» Enflurane fluoride ion, nephrotoxic metabolite were measured the blood prior to, during, up to forty-eight hours following exposure 1.9 i: 0.2 MAC enflurane» Arterial enflurane reached maximal concentrations three times faster than who similar levels eighty minutes after initiation anesthesiao gas partition coefficient for found be thirty percent lower that (1.42 ± 0.02 vs 0.99 0.02, p <0.001) may possibly explain observed differences uptake. initial rate serum inorganic appearance (5.6 yM/hour) twice seen group. maximum con­ centration both groups occurred at two post anesthesia with having sixty higher concentration (28 2 17 3 yM), indicating increased biotransformation obese. urinary excretion eight termination anesthesia. not statistically different from subjects. Hepatic biopsies demonstrated high xii fatty infiltration which related observed•