Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders.

摘要: Nesfatin-1 and ghrelin are the two recently discovered peptide hormones involved in control of appetite. Besides its main appetite-control function, also has anticonvulsant effects, while nesfatin-1 causes depolarization paraventricular nucleus (PVN). The aims this study, therefore, were to investigate: (i) whether there differences concentrations saliva serum samples between eplilepsy patients normal controls (ii) salivary glands produce nesfatin-1. study included a total 73 subjects: 8 who newly diagnosed with primary generalized seizures had started antiepileptic drug therapy; 21 continuing established 24 partial (simple: n = 12 or complex: 12) 20 controls. Salivary gland tissue analyzed for expression by immunochemistry ELISA. Saliva levels measured ELISA RIA, immunoreactivity was detected striated interlobular parts ducts. level brain around times higher than gland. Before treatment, both 160-fold epilepsy (PGE) controls; these decreased treatment but remained about 10 values. from PGE epilepsies drugs 10-fold Serum significantly (twofold) lower epileptic before they recovered somewhat below These results suggest that low especially dramatically elevated might contribute pathophyisology epilepsy. Therefore, remarkably increased be candidate biomarkers diagnosis monitoring response anti-epileptic treatment.