Impact of a T cell-based blood test for tuberculosis infection on clinical decision-making in routine practice.

作者: Sarah Gooding , Oni Chowdhury , Tim Hinks , Luca Richeldi , Monica Losi

DOI: 10.1016/J.JINF.2006.11.002

关键词:

摘要: New T cell-based blood tests for tuberculosis infection could improve diagnosis of but their clinical utility remains unknown. We describe the role ELISpot test in diagnostic work-up 13 patients presenting with suspected routine practice. Of seven a final active tuberculosis, all were positive by including three false-negative tuberculin skin results. Rapid determination accelerated enabling early treatment initiation.

参考文章(12)
P I Fujiwara, S V Cook, T R Frieden, L F Sherman, L B Bazerman, Patient and health care system delays in the diagnosis and treatment of tuberculosis. International Journal of Tuberculosis and Lung Disease. ,vol. 3, pp. 1088- 1095 ,(1999)
Ann LN Chapman, Mwansa Munkanta, Katalin A Wilkinson, Ansar A Pathan, Katie Ewer, Helen Ayles, William H Reece, Alwyn Mwinga, Peter Godfrey-Faussett, Ajit Lalvani, None, Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS. ,vol. 16, pp. 2285- 2293 ,(2002) , 10.1097/00002030-200211220-00008
Ajit Lalvani, Ansar A Pathan, Helen Mcshane, Robert J Wilkinson, Mohammed Latif, Christopher P Conlon, Geoffrey Pasvol, Adrian VS Hill, Rapid Detection of Mycobacterium tuberculosis Infection by Enumeration of Antigen-specific T Cells American Journal of Respiratory and Critical Care Medicine. ,vol. 163, pp. 824- 828 ,(2001) , 10.1164/AJRCCM.163.4.2009100
Donald R. Nash, Jesse E. Douglass, Anergy in Active Pulmonary Tuberculosis Chest. ,vol. 78, pp. 800- 801 ,(1980) , 10.1378/CHEST.78.5.800
Venkatarama K. Rao, Delays in the Suspicion and Treatment of Tuberculosis among Hospitalized Patients Annals of Internal Medicine. ,vol. 130, pp. 404- 411 ,(1999) , 10.7326/0003-4819-130-5-199903020-00004
R. E. Huebner, M. F. Schein, J. B. Bass, The tuberculin skin test Clinical Infectious Diseases. ,vol. 17, pp. 968- 975 ,(1993) , 10.1093/CLINIDS/17.6.968
Peter M Small, Mark D Perkins, More rigour needed in trials of new diagnostic agents for tuberculosis. The Lancet. ,vol. 356, pp. 1048- 1049 ,(2000) , 10.1016/S0140-6736(00)02724-0
Ajit Lalvani, Ansar A Pathan, Helen Durkan, Katalin A Wilkinson, Adam Whelan, Jonathan J Deeks, William HH Reece, Mohammed Latif, Geoffrey Pasvol, Adrian VS Hill, Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells The Lancet. ,vol. 357, pp. 2017- 2021 ,(2001) , 10.1016/S0140-6736(00)05115-1
Katie Ewer, Jonathan Deeks, Lydia Alvarez, Gerry Bryant, Sue Waller, Peter Andersen, Philip Monk, Ajit Lalvani, None, Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak The Lancet. ,vol. 361, pp. 1168- 1173 ,(2003) , 10.1016/S0140-6736(03)12950-9