The over-expression of somatostatin in the gerbil entorhinal cortex induced by seizure

摘要: In present study, we investigated the immunohistochemical distribution of somatostatin (SRIF) in hippocampal complex Mongolian gerbil and its association with different sequelae spontaneous seizures, an effort to identify roles SRIF self-recovery mechanisms these animals. dentate gyrus subiculum, immunoreactive (SRIF(+)) cells were similar both seizure resistant pre-seizure group sensitive gerbils. Interestingly, immunoreactivity was markedly decreased until 12 h postictal. Twenty-four hours after on-set seizure, regions had slightly increased. contrast, entorhinal cortex population SRIF(+) their density significantly elevated compared 30 min Twelve however, declined, approximately 70-80% situation at These findings suggest that enhancement expression may affect tissue excitability have a role modulating recurrent excitation following seizures.