Development and performance of inactivated vaccines against foot and mouth disease.

摘要: The historical background of foot and mouth disease (FMD) vaccine production is briefly described. Improvements achieved through the use monolayer suspension cultures are outlined. Elements that crucial in modern vaccines discussed, such as inactivation viral antigen, successive concentration purification antigen final formulation vaccine. Storage concentrated at ultra-low temperatures creates greater flexibility for producer has also enabled national international organisations to establish banks. FMD antigens, including removal non-structural proteins (NSPs), enables immune responses vaccinated animals be distinguished from infected with live virus. Consequently, combined purified tests detection antibodies against NSPs essentially provides a marker system distinguish between subsequently become those have not. Bearing mind good record control outbreaks possibility screening herds carriers, author proposes OIE reconsider differences requirements regaining export status following stamping-out opposed vaccination outbreak situations.