A longitudinal study on the acceptance and effects of a therapeutic renal food in pet dogs with IRIS-Stage 1 chronic kidney disease.

摘要: Summary Currently, nutritional management is recommended when serum creatinine (Cr) exceeds 1.4 mg/dl in dogs with IRIS-Stage 2 chronic kidney disease (CKD) to slow progressive loss of function, reduce clinical and biochemical consequences CKD, maintain adequate nutrition. It unknown if dietary interventions benefit non-azotemic at earlier stages. A prospective 12-month feeding trial was performed client-owned 1 CKD (n = 36; 20 had persistently dilute urine specific gravity (USG) 0.5; 10 both). Ease transition therapeutic renal food effects on biomarkers quality life attributes were assessed. Dogs transitioned over 1 week from grocery-branded foods food. At 0, 3, 6, 9, 12-months a questionnaire assess owner's perception their pet's acceptance completed. Renal biomarkers, including Cr, blood urea nitrogen (BUN), symmetric dimethylarginine (SDMA), USG UPC ratio measured. Of 36 initially enrolled, 35 (97%) moderately or extremely liked the 88% time, ate most all 84% enthusiastic while eating 76% time. All (Cr, BUN, SDMA) decreased (p ≤ .05) baseline 3-months, remained completing study (n = 20). Proteinuria reduced 12 16 (p = .045) proteinuria. Owners reported improvement overall health attributes, hair coat (all p < .01). In summary, readily Decreasing biomarker concentrations reduction proteinuria suggest stabilized function.