Biodegradation of in situ‐forming gel of poly(DLLA‐co‐CL) in vivo
作者： Chong Zhang , Xiaowei Zhang , Dan Yang , Ping Wang
DOI: 10.1002/APP.39646
关键词:
摘要: Poly(dl-lactide-co-caprolactone) was dissolved in N-methyl-2-pyrolidone (NMP) for preparing blank group formulation, and drug prepared by dissolving testosterone undecanoate (TU) as model group. These formulations rapidly gelled solvent diffusion effect after subcutaneous injection. The vivo degradation of copolymer gel rabbits investigated GPC 1H NMR results showed that no matter the contained or not, it had on rate P(DLLA-co-CL) carrier. Degradation products were absorbed excreted based metabolism. Copolymer molar composition changed slightly 3 months. structures characteristic copolymers characterized via DSC, TGA, SEM, respectively. Experimental excellent heat resistance. Crystallinity increased gradually during process. A dense cross-sectional structure formed 90 days. In addition, can be obviously found process proceeded two steps. Mechanism biodegradation bulk degradation. could well administrate release TU a sustained way without significant burst features. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3800–3808,
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