Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL

摘要: The v-abl gene in Abelson virus induces pre-B-cell lymphoma mice while the BCR/ABL oncogene is associated with chronic myelogenous leukemia and some cases of acute lymphocytic humans. Understanding mechanisms by which these oncogenes affect various cell types has been hampered a paucity experimental systems that reproduce range biological effects them. We have developed an system murine hematopoietic stem populations are infected either or retroviruses used to reconstitute lethally irradiated mice. Irrespective form activated abl, greater than 90% animals reconstituted such cells develop tumors. About 50% them myeloproliferative syndrome shares several features phase leukemia; remaining succumb lymphomas. characterized large numbers clonally derived, myeloid cells. This model will allow study mechanism abl genes precursors leukemia. Furthermore, our results demonstrate introduction into appropriate target cell, not structure gene, major determinant specificity.