TGF-β Signaling in Leukemogenesis

摘要: Transforming growth factor-β (TGF-β) signaling plays diverse roles in regulating cell proliferation, differentiation, and “stemness” a context-dependent manner. In the first section of this chapter, we outline genetic changes that attenuate TGF-β patients with acute myelogenous leukemia (AML), or blast crisis phase chronic (CML), pediatric lymphoblastic (ALL). second section, discuss recent advances stem research indicating does not always suppress leukemogenesis. fact, paradoxically sustains survival resistance to therapy CML cells are responsible for disease recurrence treated tyrosine kinase inhibitors (TKIs). We examine evidence implicating its downstream effectors Akt FOXO vivo maintenance self-renewal ability both TKI-resistant normal hematopoietic (HSCs) from which they derived. Increased knowledge complex effects may lead improved diagnostic therapeutic tools can benefit patients.