Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats.
作者： Jared Clarke , Anders Thornell , Dale Corbett , Hilkka Soininen , Mikko Hiltunen
DOI: 10.1111/J.1460-9568.2007.05807.X
关键词:
摘要: Cerebral ischaemia leads to a transient accumulation of beta-amyloid precursor protein (APP) and (Abeta) peptides adjacent the ischaemic lesion. There is conflicting evidence that APP/Abeta fragments may either enhance neuronal plasticity or be neurotoxic. The aim current study was assess effect overexpression human APP in rats on functional recovery following cerebral ischaemia. Adult APP-overexpressing (hAPP695 Tg) subjected middle artery occlusion (MCAO) had significantly smaller infarct volumes than non-transgenic littermates, yet did not perform better series sensorimotor learning tests during 6-month follow-up period. In fact, transgenic animals were found more impaired both beam-walking Morris water maze MCAO. Immunohistochemistry showed Abeta-positive staining cortex hippocampus rats. present data suggest while provide some histological neuroprotection event ischaemia, this does translate into significant recovery.
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