Cardiac Progenitor Cells in Myocardial Infarction Wound Healing: A Critical Review
作者： Michael W. Morris , Kenneth W. Liechty
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摘要: Significance: Coronary artery disease is a major cause of morbidity and mortality as the loss functional myocardium drives progressive ventricular remodeling subsequent heart failure. Medical management has significantly improved outcomes for acute myocardial infarction (MI); however, strategies are needed to regenerate prevent progression Cytotherapy using cardiac progenitor cells (PCs) holds tremendous potential; better understanding PC biology needed. Recent Advances: Reports regeneration in lower animals have been reported last decade. However, just recently, two separate models mammalian published offer potential define biology, including recruitment, differentiation, proliferation, integration. Critical Issues: Numerous clinical trials completed or ongoing evaluate possible cytotherapy options...
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