Simulation model for contrast agent dynamics in brain perfusion scans.

摘要: Standardization efforts are currently under way to reduce the heterogeneity of quantitative brain perfusion methods. A simulation model is proposed generate test data for an unbiased comparison these This provides realistic simulated patient and independent different from any computational method. The flow contrast agent solute blood through cerebral vasculature with disease-specific configurations simulated. Blood dynamics modeled as a combination convection diffusion in tubular networks. arterial microvascular arterial-input time-concentration curves wide range statuses. configured represent embolic stroke one middle artery territory physiologically plausible vascular dispersion operators major arteries tissue retention functions. These fit simpler template allow use results multiple validation studies. gamma-variate function parameters operator, boxcar exponential decay function. Such should be used create that better assess strengths weaknesses various analysis