Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

摘要: The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to cure infection. so-called kick-and-kill paradigm proposes purge these by combining latency-reversing agents with immune effectors such as cytotoxic lymphocytes. Support for this approach is largely based on success latency models, which do not fully reflect the makeup individuals long-term antiretroviral therapy (ART). Recent studies have shown that CD8+ potential recognize defective proviruses, comprise vast majority all infected cells, and proviral landscape can be shaped over time due vivo clonal expansion cells. Here, we treating from ART-treated combinations potent autologous consistently reduced cell-associated DNA, but failed deplete replication-competent virus. These recognized potently eliminated were newly reservoir virus, ruling out a role both escape cell dysfunction. Thus, our results suggest harboring possess an inherent resistance may need addressed