Insulin-like actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism.

摘要: Oral administration of tungstate for 15 days normalized glycemia in streptozotocin-induced diabetic rats. Simultaneously, the alterations hepatic glucose metabolism due to diabetes were almost completely counteracted by this treatment. Thus, 6-phosphofructo-2-kinase, L-pyruvate kinase, and glycogen phosphorylase alpha activities reached levels similar those observed healthy animals. Hepatic fructose 2,6-bisphosphate also recovered. However, recovery glucokinase activity 6-phosphate was only partial. The total synthase increased, although activation state not Moreover, mRNA glucokinase, phosphorylase, phosphoenolpyruvate carboxykinase normalized. Tungstate animals affected all these parameters, a much lesser extent. All effects previously reported vanadate, suggesting common mechanism action vivo.