Vestibular regeneration--experimental models and clinical implications.

摘要: Therapies aimed at the protection and/or regeneration of inner ear hair cells are great interest, given significant monetary and quality life impact balance disorders. Different viral vectors have been shown to transfect various cell types in ear. The past decade has provided tremendous advances use adenoviral achieve targeted treatment delivery. Several routes delivery identified introduce into while minimizing injury surrounding structures. Recently, transcription factor Atoh1 was determined play a critical role differentiation. Adenoviral-mediated overexpression culture vivo demonstrated ability regenerate vestibular by causing transdifferentiation neighbouring epithelial-supporting cells. Functional recovery system also documented following adenoviral-induced overexpression. Experiments demonstrating gene transfer human epithelial reveal that is suitable target for therapy.