Confounding by time since hire in internal comparisons of cumulative exposure in occupational cohort studies.

摘要: We use a simple, empirical model to describe the healthy worker effect mortality pattern. Under this simple model, internal comparisons of risk with increasing cumulative exposure will tend be biased away from null because effect. illustrate potential magnitude bias in situation and show that controlling for time since hire, by means standard epidemiologic methods, eliminates bias. Time hire also is concern occupational epidemiologists issue induction time; sufficient may not have elapsed among recently hired workers an manifest its on disease occurrence. Provision adequate period can addressed, like raised paper, restricting analysis first employed many years before start follow-up period. (Epidemiology 1993;4:336–341)