Stroke research in GenomEUtwin.

作者: David Gaist , Nancy L. Pedersen , Markku Koskenvuo , Søren Bak , Simona Giampaoli

DOI: 10.1375/136905203770326448

关键词:

摘要: Stroke is one of the leading causes severe disability and death in world. In present article we outline possibilities limitations for future stroke research within GenomEUtwin. The combined sample twins born before 1958 from Denmark, Finland, Sweden, available follow-up into second millennium non-fatal fatal events through national inpatient registers exceeds 70,000 twin pairs. This size will enable study genetic influences on major subtypes. Large samples GenomEUtwin have been followed up repeatedly interviews questionnaires concerning a variety exposures potential risk factors stroke. We briefly how this information can be with health register epidemiologic studies also number pairs concordant discordant Finland time lags between illustrates that affected sib linkage relatively limited, but sizes are promising association studies.

参考文章(45)
Deborah Finkel, Nancy L. Pedersen, Chandra A. Reynolds, Stig Berg, Ulf de Faire, Magnus Svartengren, Genetic and Environmental Influences on Decline in Biobehavioral Markers of Aging Behavior Genetics. ,vol. 33, pp. 107- 123 ,(2003) , 10.1023/A:1022549700943
James F Meschia, Robert D Brown, Thomas G Brott, Felix E Chukwudelunzu, John Hardy, Stephen S Rich, The Siblings With Ischemic Stroke Study (SWISS) protocol. BMC Medical Genetics. ,vol. 3, pp. 1- 12 ,(2002) , 10.1186/1471-2350-3-1
Daniel Woo, Laura R. Sauerbeck, Brett M. Kissela, Jane C. Khoury, Jerzy P. Szaflarski, James Gebel, Rakesh Shukla, Arthur M. Pancioli, Edward C. Jauch, Anil G. Menon, Ranjan Deka, Janice A. Carrozzella, Charles J. Moomaw, Robert N. Fontaine, Joseph P. Broderick, Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. ,vol. 33, pp. 1190- 1196 ,(2002) , 10.1161/01.STR.0000014774.88027.22
Caroline S. Fox, Joseph F. Polak, Irmarie Chazaro, Adrienne Cupples, Philip A. Wolf, Ralph A. D’Agostino, Christopher J. O’Donnell, Genetic and Environmental Contributions to Atherosclerosis Phenotypes in Men and Women: Heritability of Carotid Intima-Media Thickness in the Framingham Heart Study Stroke. ,vol. 34, pp. 397- 401 ,(2003) , 10.1161/01.STR.0000048214.56981.6F
D K Kiely, P A Wolf, L A Cupples, A S Beiser, R H Myers, Familial aggregation of stroke. The Framingham Study. Stroke. ,vol. 24, pp. 1366- 1371 ,(1993) , 10.1161/01.STR.24.9.1366
Ahamad Hassan, Pak C Sham, Hugh S Markus, None, Planning genetic studies in human stroke: Sample size estimates based on family history data Neurology. ,vol. 58, pp. 1483- 1488 ,(2002) , 10.1212/WNL.58.10.1483
E Lindenstrøm, G Boysen, J Nyboe, M Appleyard, Stroke incidence in Copenhagen, 1976-1988. Stroke. ,vol. 23, pp. 28- 32 ,(1992) , 10.1161/01.STR.23.1.28
Jaakko Kaprio, Urho M Kujala, Markku Koskenvuo, Seppo Sarna, Physical activity and other risk factors in male twin-pairs discordant for coronary heart disease Atherosclerosis. ,vol. 150, pp. 193- 200 ,(2000) , 10.1016/S0021-9150(99)00368-8